Systematic reviews have the highest level of evidence in every available hierarchy of evidence. They are essential part of demonstrating value of the technology, whether it is summarizing of burden of disease (e.g. prevalence of disease or mortality) or evidence of safety and efficacy of technology.
Every reimbursement/HTA submission includes systematic literature review of effectiveness and safety of technology.
It is common understanding that systematic reviews/meta-analysis is only suitable for analysis of randomized controlled trials. However, a well-developed methodology is available for review and meta-analysis of all possible types of study design, including single-arm case series studies and studies of performance of diagnostic method.
Synergus can provide support in developing and publishing results of state-of-art systematic literature reviews and meta-analysis.